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Intern
    Chair for Drug Formulation and Delivery

    Valerie Spieler

    Tel.: +49 931 31-84130

    E-Mail: valerie.spieler[at]uni-wuerzburg.de

    Research Interests

    Valerie joined the group in March ’15. She explores a new approach for local delivery of therapeutic proteins after systemic administration for treatment of inflammatory diseases. The proteins of interest are site-specifically modified (PEGylation and introduction of a protease-sensitive peptide sequence) to be specifically cleaved and released by upregulated enzymes at the site of inflammation.

    Curriculum Vitae

    10/2009-07/2012
    Bachelor studies of Biomolecular Engineering, Technische Universität Darmstadt

    10/2012-09/2014
    Master studies of Biomolecular Engineering, Technische Universität Darmstadt

    2015-present
    Scientist, Dept. of Pharmacy and Food Chemistry, Chair of Pharmaceutics and Biopharmacy, University of Würzburg

    Publications/Posters

    Lühmann, T., Schmidt, M., et al. (2016). "Site-specific POxylation of Interleukin-4." ACS Biomater Sci Eng. 2016 Dec 12, doi: 10.1021/acsbiomaterials.6b00578, [Epub ahead of print]. http://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.6b00578

    Lühmann, T., Spieler, V., et al. (2016). "Interleukin-4 clicked surfaces drive M2 macrophage polarization."  Chembiochem. 2016 Nov 17, 17(22), pp. 2123-2128. www.ncbi.nlm.nih.gov/pubmed/27595549

    Spieler, V., Valldorf, B., et al. (2016). "Coupled reactions on bioparticles: Stereoselective reduction with cofactor regeneration on PhaC inclusion bodies." Biotechnol. J. 2016 July, 11(7), pp. 890-898. www.dx.doi.org/10.1002/biot.201500495

    Lühmann, T., Spieler, V. (2016). "67th Mosbacher Kolloquium: Protein Design: From First Principles to Biomedical Applications." ChemBioChem. 2016 July 15, 17(14), pp. 1297-1300. www.dx.doi.org/10.1002/cbic.201600256