Chair for Drug Formulation and Delivery

    Tessa Lühmann

    PD Dr. Tessa Lühmann

    Tel.: +49 931 31-82807

    E-Mail: tessa.luehmann[at]uni-wuerzburg.de


    Tessa joined the group in February ´11. She studied biochemistry at the University of Leipzig and accomplished her PhD 2009 in the group of Heike Hall at ETH Zurich (Department of Materials). During her thesis she aimed to improve nerve regeneration in the peripheral nervous system by diverse in vitro approaches in order to direct cellular growth by modified nanofibers and covalently attached guidance cues in fibrin gels. She also gained interest in polymeric non-viral gene delivery systems, which might help to provide growth factors and/or guidance cues in (re)generative tissues.

    With a specific interest in regenerative medicine Tessa`s present research focuses on novel engineered proteins with enhanced pharmakokinetc properties, biomaterial design for tissue engineering and analytical techniques for the evaluation of protein stability at the molecular level.

    Curriculum Vitae 

    July 2013 – December 2013
    Visiting Scholar, Massachusetts Institute of Technology (MIT), Department of Chemistry, Cambridge, USA.

    June 2013
    Habilitation candidate.

    2011 – present
    Senior associate scientist at the Chair for Pharmaceutical Technology, Institute for Pharmacy and Food Chemistry, University of Wurzburg.

    2009 – 2010
    Postdoc at the Laboratory of Biologically Oriented Materials, Department of Materials, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland.

    2006 – 2009
    Doctoral student at the Laboratory of Biologically Oriented Materials, Department of Materials, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland.

    2001 – 2006
    Studies of Biochemistry at the University of Leipzig and at the Swiss Federal Institute of Technology (ETH) Zurich, Switzerland.

    1994 – 2001
    Theodor-Heuss Gymnasium, Wolfsburg. 


    Different in vitro approaches to improve nerve regeneration, Department of Material Science, ETH Zurich, Switzerland


    2014 Galenus support

    2013 Bavarian research foundation, travel support

    2013 Participant 63rd Lindau Nobel Laureate Meeting

    2005 Erasmus fellowship


    Publication list

    Dodt, K., Lamer, S., et al. (2020). "Mass-encoded reporters reporting proteolytic activity from within the extracellular matrix." ACS Biomater. Sci. Eng.  2020 Jul 30, doi.org/10.1021/acsbiomaterials.0c00691, [Epub ahead of print]. https://pubs.acs.org/doi/10.1021/acsbiomaterials.0c00691

    Spieler, V., Ludwig, M.-G., et al. (2020). "Targeting interleukin-4 to the arthritic joint ." J Control Release. 2020 Oct 10, 326, pp. 172-180. doi: 10.1016/j.jconrel.2020.07.005. https://www.sciencedirect.com/science/article/abs/pii/S0168365920303801

    Lorson, T., Ruopp, M., et al. (2020). “Sterilization Methods and Their Influence on Physicochemical Properties and Bioprinting of Alginate as a Bioink Component." ACS Omega. 2020, 5, 12, 6481-6486, doi.org/10.1021/acsomega.9b04096. https://pubs.acs.org/doi/pdf/10.1021/acsomega.9b04096 

    Lühmann, T., Gutmann, M., et al. (2020). “Biodistribution of site-specifically PEGylated fibroblast growth factor-2.” ACS Biomater Sci Eng. 2020, 6, 1, 425-432, doi.org/10.1021/acsbiomaterials.9b01248. https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.9b01248

    Gutmann, M., Bechold, J., et al. (2018). “Metabolic glycoengineering of cell derived matrices and cell surfaces – a combination of key principles and step-to-step procedures.” ACS Biomater Sci Eng. 2018 Nov 20, doi: 10.1021/acsbiomaterials.8b00865  [Epub ahead of print]. https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.8b00865

    Braun, A.C., Gutmann, M., et al. (2018). "Bioresponsive release of insulin-like growth factor-I from its PEGylated conjugate." J Control Release. 2018 Apr 7, doi: 10.1016/j.jconrel.2018.04.009, [Epub ahead of print]. https://www.sciencedirect.com/science/article/pii/S0168365918301913

    Gutmann, M., Braun, A., et al. (2018). "Bioorthogonal Modification of Cell Derived Matrices by Metabolic Glycoengineering." ACS Biomater Sci Eng. 2018 Mar 13, doi: 10.1021/acsbiomaterials.8b00264, [Epub ahead of print]. https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.8b00264

    Wu, F., Braun, A., et al. (2018). "Site-Specific Conjugated Insulin-like Growth Factor‑I for Anabolic Therapy." ACS Biomater Sci Eng. 2018 Feb 12, doi: 10.1021/acsbiomaterials.7b01016, [Epub ahead of print]. https://pubs.acs.org/doi/pdfplus/10.1021/acsbiomaterials.7b01016

    Braun, A.C., Gutmann, M., et al. (2018). "Bioorthogonal strategies for site-directed decoration of biomaterials with therapeutic proteins." J Control Release. 2018 Jan 19, doi: 10.1016/j.jconrel.2018.01.018, [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/29360478

    Wiest, J., Saedtler, M., et al. (2017). "Mapping the pharmaceutical design space by amorphous ionic liquid strategies." J Control Release. 2017 Oct 30, doi: 10.1016/j.jconrel.2017.10.040., [Epub ahead of print].https://www.ncbi.nlm.nih.gov/pubmed/29097303

    Sevim, S., Özer, S., et al. (2017). "Nanomechanics on FGF-2 and heparin reveal slip bond characteristics with pH dependency." ACS Biomater Sci Eng. 2017 Mar 28, doi: 10.1021/acsbiomaterials.6b00723, [Epub ahead of print]. pubs.acs.org/doi/abs/10.1021/acsbiomaterials.6b00723

    Moscaroli, A., Jones, G., et al. (2017). "Radiolabeled 111In-FGF-2 Is Suitable for In Vitro/Ex Vivo Evaluations and In Vivo Imaging." Mol. Pharmaceutics. 2017 Feb 21, doi: 10.1021/acs.molpharmaceut.6b00913, [Epub ahead of print]. http://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.6b00913 

    Tabisz, B., Schmitz, W., et al. (2017). "Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds." Biomacromolecules.  2017 Feb 17, doi: 10.1021/acs.biomac.6b01407, [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/28211679

    Lühmann, T., Schmidt, M., et al. (2016). "Site-specific POxylation of Interleukin-4." ACS Biomater Sci Eng. 2016 Dec 12, doi: 10.1021/acsbiomaterials.6b00578, [Epub ahead of print]. http://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.6b00578

    Wandrey, G., Wurzel, J., et al. (2016). "Probing unnatural amino acid integration into enhanced green fluorescent protein by genetic code expansion with a high-throughput screening platform." J Biol Eng. 2016 Sep 30, 10:11. https://jbioleng.biomedcentral.com/articles/10.1186/s13036-016-0031-6 

    Griesbeck, S., Zhang, Z., et al. (2016). "Water-Soluble Triarylborane Chromophores for One- and Two-Photon Excited Fluorescence Imaging of Mitochondria in Cells." Chemistry. 2016 Oct 4, 22(41), pp. 14701-6. http://www.ncbi.nlm.nih.gov/pubmed/27627995

    Braun, A.C., Gutmann, M., et al. (2016). "Matrix Metalloproteinase Responsive Delivery of Myostatin Inhibitors." Pharm Res. 2017 Jan, 34(1), pp. 58-72. http://www.ncbi.nlm.nih.gov/pubmed/27628627

    Sevim, S., Ozer, S., et al. (2016). "Dually actuated atomic force microscope with miniaturized magnetic bead-actuators for single-molecule force measurements." Nanoscale Horiz. 2016, 1, pp. 488-495. http://pubs.rsc.org/-/content/articlehtml/2016/nh/c6nh00134c

    Lühmann, T., Spieler, V., et al. (2016). "Interleukin-4 clicked surfaces drive M2 macrophage polarization."  Chembiochem. 2016 Nov 17, 17(22), pp. 2123-2128. www.ncbi.nlm.nih.gov/pubmed/27595549

    Lühmann, T., Spieler, V. (2016). "67th Mosbacher Kolloquium: Protein Design: From First Principles to Biomedical Applications." ChemBioChem. 2016 July 15, 17(14), pp 1297-1300. www.dx.doi.org/10.1002/cbic.201600256

    Dechnik, J., Mühlbach, F., et al. (2016). "Luminescent Metal–Organic Framework Mixed-Matrix Membranes from Lanthanide Metal–Organic Frameworks in Polysulfone and Matrimid." Eur. J. Inorg. Chem. 2016, 27, pp.4408-4415. www.onlinelibrary.wiley.com/doi/10.1002/ejic.201600235/abstract

    Lühmann, T., Mong, S.K., et al. (2016). "A perfluoroaromatic abiotic analog of H2 relaxin enabled by rapid flow-based peptide synthesis." Org Biomol Chem. 2016 Apr 7, 14(13), pp. 3345-9. www.ncbi.nlm.nih.gov/pubmed/26954512

    Gutmann, M., Memmel, E., et al. (2016). "Biocompatible Azide Alkyne"Click" Reactions for Surface Decoration of Glyco-Engineered Cells." Chembiochem. 2016 May 3, 17(9), pp. 866-75. www.ncbi.nlm.nih.gov/pubmed/26818821

    Pokki, J., Ergeneman, O., et al. (2016). "Protective coatings for intraocular wirelessly controlled microrobots for implantation: Corrosion, cell culture, and in vivo animal tests." J Biomed Mater Res B Appl Biomater. 2016 Jan 24, [Epub ahead of print]. www.ncbi.nlm.nih.gov/pubmed/26804771

    Lühmann, T., Meinel, L. (2016). “Nanotransporters for drug delivery.” Current opinion in Biotechnology 2016, 39, pp. 35-40. www.sciencedirect.com/science/article/pii/S0958166915001767

    Firdessa, R., Good, L., et al. (2015). "Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB)." PLoS Negl Trop Dis. 2015 Oct 2, 9(10): e0004041. doi:10.1371/journal.pntd.0004041.eCollection 2015. www.ncbi.nlm.nih.gov/pubmed/26431058

    Brügger, V., Engler, S., et al. (2015). "HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins." PLoS Biol 13(9): e1002258. doi: 10.1371/journal.pbio.1002258. eCollection 2015. www.ncbi.nlm.nih.gov/pubmed/26406915

    Lühmann, T., Jones, G., et al. (2015). "Bio-orthogonal Immobilization of Fibroblast Growth Factor 2 for Spatial Controlled Cell Proliferation." ACS Biomater Sci Eng 2015, 1(9), pp. 740-746. pubs.acs.org/doi/abs/10.1021/acsbiomaterials.5b00236

    Schultz, I., Vollmers, F., et al. (2015) “Pulmonary Insulin-like growth factor I delivery from trehalose and silk-fibroin microparticles.” ACS Biomater Sci Eng Accepted pubs.acs.org/doi/abs/10.1021/ab500101c

    Balk, A., Widmer, T., et al. (2014). "Ionic Liquid Versus Prodrug Strategy to Address Formulation Challenges." Pharm Res Ahead of print. www.ncbi.nlm.nih.gov/pubmed/25534684

    Germershaus, O., Luehmann, T., et al. (2015). "Application of natural and semi-synthetic polymers for the delivery of sensitive drugs" Int Mater Rev 60(2): 101-131. www.maneyonline.com/doi/full/10.1179/1743280414Y.0000000045

    Chen, Y., Pidhatika, B., et al. (2014). "Comparative assessment of the stability of nonfouling poly(2-methyl-2-oxazoline) and poly(ethylene glycol) surface films: An in vitro cell culture study." Biointerphases 9(3): 031003. www.ncbi.nlm.nih.gov/pubmed/25280844

    Steiger, C., Lühmann, T., et al. (2014). "Oral drug delivery of therapeutic gases -carbon monoxide release for gastrointestinal diseases." J Control Release 189: 46-53. www.ncbi.nlm.nih.gov/pubmed/24969354

    Zhao, H., Heusler, E., et al. (2014). "Decoration of silk fibroin by click chemistry for biomedical application." J Struct Biol, 186(3): 420-430 www.ncbi.nlm.nih.gov/pubmed/24576682

    Möller, J., Lühmann, T., et al. (2013). "Macrophages lift off surface-bound bacteria using a filopodium-lamellipodium hook-and-shovel mechanism." Sci Rep 3: 2884 www.ncbi.nlm.nih.gov/pubmed/24097079

    Suter, M., Zhang, L., et al. (2013). "Superparamagnetic microrobots: fabrication by two-photon polymerization and biocompatibility." Biomed Microdevices www.ncbi.nlm.nih.gov/pubmed/23846247

    Germershaus, O., Schultz, I., et al. (2013). "Insulin-like growth factor-I aerosol formulations for pulmonary delivery." Eur J Pharm Biopharm 85(1): 61-68. www.ncbi.nlm.nih.gov/pubmed/23958318

    Binder, C., Milleret, V., et al. (2013). "Influence of micro and submicro poly(lactic-glycolic acid) fibers on sensory neural cell locomotion and neurite growth." J Biomed Mater Res B Appl Biomater www.ncbi.nlm.nih.gov/pubmed/23650277

    Thiersch, M., Rimann, M., et al. (2013). "The angiogenic response to PLL-g-PEG-mediated HIF-1α plasmid DNA delivery in healthy and diabetic rats." Biomaterials www.ncbi.nlm.nih.gov/pubmed/23465832

    Horn, M., Baumann, R., et al. (2012). "Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells." Brain 135(Pt 12): 3567-3583. www.ncbi.nlm.nih.gov/pubmed/23171661

    Meinel, A. J., Germershaus, O., et al. (2012). "Electrospun matrices for localized drug delivery: Current technologies and selected biomedical applications." Eur J Pharm Biopharm. www.ncbi.nlm.nih.gov/pubmed/22342778

    Moller, J., Luehmann, T., et al. (2012). "The Race to the Pole: How High-Aspect Ratio Shape and Heterogeneous Environments Limit Phagocytosis of Filamentous Escherichia coli Bacteria by Macrophages." Nano Lett. www.ncbi.nlm.nih.gov/pubmed/22591454

    Pokki, J., Ergeneman, O., et al. (2012). "Electroplated porous polypyrrole nanostructures patterned by colloidal lithography for drug-delivery applications." Nanoscale 4(10): 3083-3088. www.ncbi.nlm.nih.gov/pubmed/22422198

    Sivaraman, K. M., Kellenberger, C., et al. (2012). "Porous polysulfone coatings for enhanced drug delivery." Biomed Microdevices 14(3): 603-612. www.ncbi.nlm.nih.gov/pubmed/22391877

    Sivaraman, K. M., Ozkale, B., et al. (2012). "Redox Cycling for Passive Modification of Polypyrrole Surface Properties: Effects on Cell Adhesion and Proliferation." Adv Healthc Mater. www.ncbi.nlm.nih.gov/pubmed/23197463

    Luhmann, T., Germershaus, O., et al. (2011). "Bone targeting for the treatment of osteoporosis." J Control Release. www.ncbi.nlm.nih.gov/pubmed/22016072

    von Erlach, T., Zwicker, S., et al. (2011). "Formation and characterization of DNA-polymer-condensates based on poly(2-methyl-2-oxazoline) grafted poly(L-lysine) for non-viral delivery of therapeutic DNA." Biomaterials 32(22): 5291-5303. www.ncbi.nlm.nih.gov/pubmed/21514664

    Pereira, J. A., Baumann, R., et al. (2010). "Dicer in Schwann cells is required for myelination and axonal integrity." J Neurosci 30(19): 6763-6775. www.ncbi.nlm.nih.gov/pubmed/20463238

    Luhmann, T. and Hall, H. (2009). "Cell Guidance by 3D-Gradients in Hydrogel Matrices: Importance for Biomedical Applications." Materials 2(3): 1058-1083. www.mdpi.com/1996-1944/2/3/1058

    Luhmann, T., Hanseler, P., et al. (2009). "The induction of cell alignment by covalently immobilized gradients of the 6th Ig-like domain of cell adhesion molecule L1 in 3D-fibrin matrices." Biomaterials 30(27): 4503-4512. www.ncbi.nlm.nih.gov/pubmed/19523683

    David, R., Gunther, R., et al. (2008). "Artificial chemokines: combining chemistry and molecular biology for the elucidation of interleukin-8 functionality." Journal of the American Chemical Society 130(46): 15311-15317. www.ncbi.nlm.nih.gov/pubmed/18942784

    Luhmann, T., Rimann, M., et al. (2008). "Cellular uptake and intracellular pathways of PLL-g-PEG-DNA nanoparticles." Bioconjugate Chemistry 19(9): 1907-1916. www.ncbi.nlm.nih.gov/pubmed/18717536

    Rimann, M., Luhmann, T., et al. (2008). "Characterization of PLL-g-PEG-DNA nanoparticles for the delivery of therapeutic DNA." Bioconjugate Chemistry 19(2): 548-557. www.ncbi.nlm.nih.gov/pubmed/18173226