Tel.: +49 931 31-83857
Johannes joined the group in April ’15. He studied pharmacy at the Julius-Maximilians-Universität Wuerzburg and obtained his PhD in the group of Prof. Dr. U. Holzgrabe (Institute for Pharmacy and Food Chemistry) at the University of Wuerzburg. During his PhD thesis, he was working on the synthesis and characterization of novel Ionic Liquids (IL) based on a poorly water soluble AMPA receptor antagonist against migraine.
His present research is focused on:
• Development of light-controlled phase transition systems for tuning solubility and skin penetration of drugs by cis-trans isomerization of the counterions.
• Ionic Liquid approach to improve the dissolution rate and solubility of poorly water soluble drugs
• Study of supersaturation effects and use in vivo
• Synthesis of new counterions and salts of poorly water soluble drugs
For his research he is using a broad range of different techniques:
• Nuclear Magnetic Resonance Spectroscopy (NMR)
• Infrared Spectroscopy (IR)
• X-Ray Powder Diffraction (XRPD)
• Differential Scanning Calorimetry (DSC)
• Isothermal Titration Calorimetry (ITC)
• High Performance Liquid Chromatography (HPLC)
• SiriusT3 Instrument
Studies of Pharmacy, University Wuerzburg
Practical year in pharmacy and industry
License to practice Pharmacy ('Approbation als Apotheker')
PhD thesis at the Institute for Pharmacy and Food Chemistry, Medicinal Chemistry in the group of Prof. Dr. U. Holzgrabe
Postdoctoral fellow at the Department for Pharmaceutics and Biopharmacy in the group of Prof. Dr. Dr. L. Meinel
Wiest, J., Saedtler, M., et al. (2018). “Geometrical and Structural Dynamics of Imatinib within Biorelevant Colloids.” Mol Pharm. 2018 Aug 28, doi: 10.1021/acs.molpharmaceut.8b00469., [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/30111113
Reggane, M., Wiest, J., et al. (2018). "Bioinspired co-crystals of Imatinib providing enhanced kinetic solubility." Eur J Pharm Biopharm. 2018 May 4, doi: 10.1016/j.ejpb.2018.05.012, [Epub ahead of print]. https://www.sciencedirect.com/science/article/pii/S0939641118304429
Wiest, J., Saedtler, M., et al. (2017). "Mapping the pharmaceutical design space by amorphous ionic liquid strategies." J Control Release. 2017 Oct 30, doi: 10.1016/j.jconrel.2017.10.040., [Epub ahead of print].
Balk, A., Wiest, J., et al (2015). "Transformation of acidic poorly water soluble drugs into ionic liquids." Eur J Pharm Biopharm 2015, 94, pp. 73–82.
M. Mülek, A. Fekete, J. Wiest, U. Holzgrabe, M.J. Mueller, P. Högger, Profiling a gut microbiota-generated catechin metabolite's fate in human blood cells using a metabolomic approach, J. Pharm. Biomed. Anal., 114 (2015), 71-81.
A. Balk, T. Widmer, J. Wiest, H. Bruhn, J.-C. Rybak, P. Matthes, K. Müller-Buschbaum, A. Sakalis, T. Lühmann, J. Berghausen, U. Holzgrabe, B. Galli, L. Meinel, Ionic Liquid Versus Prodrug Strategy to Address Formulation Challenges, Pharm. Res., 32 (2014), 2154-2167.
J. Wiest, C. Schollmayer, G. Gresser, U. Holzgrabe, Identification and quantitation of the ingredients in a counterfeit Vietnamese herbal medicine against rheumatic diseases, J. Pharm. Biomed. Anal. 97 (2014), 24-8.
A. L. Schmitz, R. Schrage, E. Gaffal, T. H. Charpentier, J. Wiest, G. Hiltensperger, J. Morschel, S. Hennen, D. Haussler, V. Horn, D. Wenzel, M. Grundmann, K. M. Bullesbach, R. Schroder, H. H. Brewitz, J. Schmidt, J. Gomeza, C. Gales, B. K. Fleischmann, T. Tuting, D. Imhof, D. Tietze, M. Gutschow, U. Holzgrabe, J. Sondek, T. K. Harden, K. Mohr, E. Kostenis, A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation, Chem. Biol. 21 (2014), 890-902.
M. Hohmann, C. Felbinger, N. Christoph, H. Wachter, J. Wiest, U. Holzgrabe, Quantification of taurine in energy drinks using 1H NMR, J. Pharm. Biomed. Anal. 93, (2014), 156-60.