Chair for Drug Formulation and Delivery

    Solubilisation of Imatinib in GIF


    Johannes Wiest published an article in ‘Molecular Pharmaceutics’ entitled “Geometrical and structural dynamics of Imatinib within biorelevant colloids." The article details the solubilization of Imatinib in simulated gastrointestinal fluids at the molecular levels. The article provides a blueprint for further studies aiming at improving bioavailability of poorly water-soluble drugs by effectively deploying the natural micelle dynamics while maximizing bioavailability. Congratulations to Johannes & team!



    Graphical abstract is reprinted with permission from:

    „Wiest, J., Saedtler, M., Böttcher, B., Grüne, M., Reggane, M., Galli, B.; Holzgrabe, U., Meinel, L. (2018). Geometrical and Structural Dynamics of Imatinib within Biorelevant Colloids. ACS Mol. Pharmaceutics.  2018 Aug 15, doi: 10.1021/acs.molpharmaceut.8b00469  [Epub ahead of print, Article ASAP].”

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