Pros and cons of ionic liquids (ILs)15.06.2015
Ionic liquids typically result from melting point depression of API salts as compared to akin salts with small counterions. Although this depression may positively drive pharmaceutical parameters including the dissolution rate or solubility some caveats apply. Anja Balk and colleagues discuss the “pro et contra” of using ionic liquid approaches for pharmaceutical application.
“Reprinted from European Journal of Pharmaceutics and Biopharmaceutics, Balk A., Holzgrabe U., Meinel L., ‘Pro et contra’ ionic liquid drugs – Challenges and opportunities for pharmaceutical translation, 2015, 94, pp. 291-304, Copyright 2015 June 9, with kind permission from Elsevier.”