Bio-orthogonal Immobilization of FGF-210.08.2015
Site specific labeling of biologics is important to further improve the quality of drug-biologic conjugates. Tessa Lühmann and her team have addressed this challenge for FGF-2 - a potent anabolic growth factor – by introducing unnatural amino acids into FGF-2 through genetic engineering. Thereby, non-natural functional groups are introduced into the biologic thereby allowing site specific decoration. Congratulations to this successful and inspiring contribution!
Graphical abstract is reprinted with permission from Lühmann, T., Jones, G., Gutmann, M., Rybak, J.-C., Nickel, J., Rubini, M., Meinel, L. (2015). Bio-orthogonal Immobilization of Fibroblast Growth Factor 2 for Spatial Controlled Cell Proliferation. ACS Biomaterials Science & Engineering, [Epub ahead of print, Article ASAP], Copyright 2015 American Chemical Society.
ACS Biomater. Sci. Eng., Article ASAP