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    Chair for Drug Formulation and Delivery

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    Dr. Lühmann concluded her Habilitation on June 28, 2017. Her talk entitled ‘Bioinspired drug delivery systems’ outlined her research of the last year. The institute and chair are very proud and honored as of her superb achievements!

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    Well done, Gabriel!

    14.09.2017

    Congratulations to Gabriel Jones! As of September 4, 2017 he successfully defended his thesis entitled „Bioinspired FGF-2 delivery for pharmaceutical application“.

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    As part of a student’s day under the motto "Experience practice - a day in the pharmaceutical industry", the company Dr. Pfleger Pharmaceuticals invited pharmacy students from Würzburg to visit the production site in Bamberg. After short company presentations on the topics of manufacturing, quality control and product management, the young pharmacists were able to gain insight into the state of the art and GMP-compliant drug development and production. A discussion session with all participants concluded the eventful student's day. We would like to thank all involved organizers of Dr. Pfleger for the close and intensive support, as well as for an exciting and informative day in Bamberg.

     

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    Dr. Steiger and colleagues visited the Guangzhou First Municipal People's Hospital in china this month. This exchange between German and Chinese researchers and medical practitioners was planned to establish intercultural exchange in both scientific and medical practise. Thanks to Prof. Wei-De Zhong and his team for planning this highly instructive journey.

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    First nanomechanical insights into the FGF-2-heparin interaction at the molecular level! Congratulations to Gabriel, Joel and Tessa and their EU consortium MANAQA! They used a single molecular study as basis to decipher the underlying nanomechanical mechanism of the binding between FGF-2 and heparin at different force levels and pH-values. The modular atomic force microscope (AFM) design with magnetic actuators may open novel avenues to study unfolding kinetics in various pharmaceutical formulations at a molecular scale.

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    Congratulations to Nina! In a truly basic-galenical contribution she presents the formulation of poorly water soluble NOX inhibitors in microemulsion and spray dried powders (oral use) and cyclodextrins (parenteral). Congratulations again to an elegant piece of work!

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    Congratulations to our coworkers from the PSI (Paul Scherrer institute) and to Gabriel, Tessa and Lorenz for co-authoring a manuscript about a novel bioconjugation approach based on thiol-mediated radioactive labeling of FGF-2 suitable for Single Photon Emission Computed Tomography (SPECT) imaging in mice. We are looking forward to continuing our successful cooperation for future PK studies of our genetically modified FGF-2 analogs!

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    Lorenz Meinel co-authored an article published in ‘The Lancet Infectious Diseases’ outlining the use of topical azithromycin for the prevention of Lyme Borreliosis.The studies assessed the in vivo eradication of Borrelia burgdorferi sensu lato by use of azithromycin gel after a tick bite.

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    Congratulations to Tessa, Valerie & team for their contribution in the bioengineering of biologics! Together with the University of Jena, they decorated Interleukin-4 (IL-4) site specifically with polymers and detailed synthesis routes for efficient yield.

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    Delegations from the University of Soochow and Zhejiang University visited the Chair of Pharmaceutics and Biopharmacy from November 25 to December 6, 2017 The University of Würzburg shares a joint research project with the two Chinese universities entitled “Macrophage Plasticity Deployed for Efficient Bone (Re-)generation” (GZ1094).

     

    The Chair of Pharmaceutics and Biopharmacy focus is on the synthesis of medical compounds, whereas the Zhejiang University provides animal models for osteoarthritis and performs pre-clinical tests with the developed constructs. In inspiring discussions, the project was thoroughly discussed and further tasks were distributed among the partners.

     

    The delegates from Soochow University are experts on biomaterials, especially silk. As a biocompatible and extraordinarily robust biomaterial, silk is going to be used for printing 3D models (for 3D tissue culture / wound dressings) with the currently implemented 3D printer in Würzburg.

     

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    Congratulations to Marcus Gutmann. He is winner of the annual poster price of the ChemSyStM 2016 (Chemie-Symposium der Studierenden Mainfrankens).

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    Lorenz Meinel has been elected as Chair of the Ph. Eur. Group of Experts 13H. Based on that, he got appointed by the European Pharmacopoeia Commission.

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    From 25th of November to 07th of December the Institute of Pharmacy is hosting guests from China, who are part of the Sino German Program between our Institute, Soochow University and Zheijiang University.

     

    The research focus is on both bioresponsive drug delivery strategies for the treatment of osteoarthritis and new approaches for tissue engineering to support musculoskeletal (re-)generation.

     

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