- Development of native and modified amino acid sequences, which are responsively cleaved by proteases ('cleavable linker'). Synthesis is by solid state peptide synthesis.
- Connecting the cleavable linker to new chemical entities/biologics or polymers to control pharmacokinetics. Areas of active projects include:
- Profiling the human tongue as a 24/7 available detector for inflammatory diseases of the oral cavity
- Bioresponsive unloading of peptide drugs at sites of sarcopenic/cachectic muscle
- Bioresponsive unloading of antibiotics to bacteria
Schlottig, F., Schnabelrauch, M., Meinel, L., Wyrwa, R. (2013). Coating for a fixed dental device for the diagnosis of peri-implantitis via a change in the coating directly detectable by the user, PCT Int. Appl., WO 2013131994 A2 20130912.
Schnabelrauch, M., Meinel, L., Schlottig, F., Wyrwa, R., A diagnostic chewing gum for the detecting inflammatory tissues in the mouth, particular peri-implantitis, via a change directly detectable by user, PCT Int. Appl., WO 2013131993 A2 20130912.
Meinel, L., Schnabelrauch, M., Schlottig, F. (2013) Diagnostic chewing gum for pathogens. PCT Int. Appl., WO 2013132058 A1 20130912.