piwik-script

Intern
    Chair for Drug Formulation and Delivery

    Biologics

    • Introduction of artificial amino acids into Biologics by genetic engineering, in order to create site directed derivatives at this position with complete control of the quality of the resulting conjugates. We apply this technique for:
      • PEGylation
      • 'Clicking' of small molecules to Biologics
      • 'Clicking' of Biologics to surfaces/implants
      • 'Clicking' of dyes to Biologics
    • Liquid and lyophilized formulations for parenteral application
    • Particular and electrospun drug release systems from synthetic (PLA, PLGA, PCA) and biopolymers (silk fibroin)

    Publication Highlights

    Schultz, I., Vollmers, F., et al. (2015) “Pulmonary Insulin-like growth factor I delivery from trehalose and silk-fibroin microparticles.” ACS Biomater Sci Eng Accepted http://pubs.acs.org/doi/abs/10.1021/ab500101c

    Germershaus, O., Luehmann, T., et al. (2015). "Application of natural and semi-synthetic polymers for the delivery of sensitive drugs" Int Mater Rev 60(2): 101-131. http://www.maneyonline.com/doi/full/10.1179/1743280414Y.0000000045

    Zhao, H., Heusler, E., et al. (2014). "Decoration of silk fibroin by click chemistry for biomedical application." J Struct Biol 186(3): 420-430 http://www.ncbi.nlm.nih.gov/pubmed/24576682